Evaluasi Sifat Fisik Tablet Floating Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Dengan Kombinasi Xanthan Gum Dan HPMC Sebagai Polimer
Keywords:
Tablet Floating, Daun Kelor (Moringa oleifera L.), Xanthan Gum, HPMC
Abstract
Moringa leaves (Moringa oleifera L.) have gastroprotective activity, making them suitable for use in floating tablets to prolong the residence time of drugs in the stomach. Floating tablets typically use xanthan gum and hydroxypropyl methylcellulose (HPMC) polymers as drug release matrices. This study aims to evaluate the physical properties of floating tablets made from ethanol extract of moringa leaves with a combination of xanthan gum and HPMC, as well as to determine the appropriate polymer concentration. Experimental studies were conducted with three formulas: F1 (15% xanthan gum; 5% HPMC), F2 (10% xanthan gum; 10% HPMC), and F3 (5% xanthan gum; 15% HPMC), using the wet granulation method. The physical properties of the granules were evaluated by testing the flow rate, Carr index, and Hausner ratio, then molded into 750 mg tablets and evaluated for physical properties (n = 3), including organoleptic properties, weight uniformity, size, hardness, friability, and floating test in 0.1 N HCl medium (pH 1.2; 37 ± 0.5 °C). The results showed that all formulations did not meet the weight uniformity and friability test (> 1%). Size uniformity and hardness (4–8 kg) met the requirements. The floating test showed that no formula was able to float for up to 30 minutes (floating lag time > 30 minutes; floating time = 0 minutes). It was concluded that the combination of xanthan gum and HPMC in the range of 5–15% did not produce moringa leaf extract floating tablets that met the physical parameters and floating test.
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Azizah, N., Noval, N., & Sudarsono, P. V. (2023). Optimasi formulasi tablet lepas lambat ekstrak seledri (Apium graveolens L.) menggunakan polimer xanthan gum dan lubrikan magnesium stearat dengan metode simplex lattice design (SLD). Jurnal Surya Medika, 9(1), 180–194. https://doi.org/10.33084/jsm.v9i1.5165
Choiri, S., Sulaiman, T. N. S., & Rohman, A. (2020). Assessment of the effect of polymers combination and effervescent component on the drug release of swellable gastro-floating tablet formulation through compartmental modeling-based approach. Drug Development and Industrial Pharmacy, 46(1), 146–158. https://doi.org/10.1080/03639045.2019.1711387
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Kurniawati, E. (2015). Daya Antibakteri ekstrak etanol tunas bambu apus terhadap bakteri Escherichia coli dan Staphylococcus aureus secara in vitro. Jurnal Wiyata, 2(2), 193–199.
Lamadjido, S. R., Umrah, U., & Jamaluddin, J. (2019). Formulasi dan analisis nilai gizi bakso kotak dari jamur tiram putih (Pleurotus ostreatus). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 5(2), 166–174. https://doi.org/10.22487/j24428744.2019.v5.i2.13149
Lestari, E., Sunarno, S., & Kasiyati, K. (2020). Efek bahan aditif tepung kelor terhadap biomassa organ visceral ayam petelur jantan. Media Bina Ilmiah, 14(9), 3215–3230. http://ejurnal.binawakya.or.id/index.php/MBI/article/view/551
Noorjannah, & Noval. (2020). Uji disolusi terbanding antara sediaan tablet ramipril generik dan bermerek. Journal of Pharmaceutical Care and Science, 1(1), 45–54. https://ejurnal.unism.ac.id/index.php/jpcs/article/view/33
Permata Hati, M., Syukri, Y., & Hernawan Nugroho, B. (2022). Pengaruh kombinasi matriks terhadap karakter tablet metformin HCl lepas lambat sistem floating effervescent. Pharmaceutical Journal of Indonesia, 7(2), 89–96. https://doi.org/10.21776/ub.pji.2022.007.02.3
Rama Koteswararao, & Lankalapalli, D (2019).Formulation and evaluation of gastroretentive floating tablets. Journal of Drug Delivery & Therapeutics, 9(4), 173–180. https://doi.org/10.22270/jddt.v11i3-S.4828
Saputri, Y. L., Nawangsari, D., & Samodra, G. (2022). Formulasi dan evaluasi tablet hisap ekstrak kulit pisang raja (Musa X paradisiaca L.) menggunakan polivinil pirolidon (PVP). Jurnal Mandala Pharmacon Indonesia, 8(2), 262–274. https://doi.org/10.35311/jmpi.v8i2.249
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Sari, S. P., Bestari, A. N., & Sulaiman, T. N. S. (2019). Optimasi formula tablet floating famotidin menggunakan kombinasi matriks gum xanthan dan hidroksi propil metil selulosa K100M. Majalah Farmaseutik, 15(2), 86. https://doi.org/10.22146/farmaseutik.v15i2.46878
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Setyorini, E., Irawan, E. D., Oktora, L., & Kumala, R. (2016). Optimasi hydroxypropyl methylcellulose dan xanthan gum pada tablet floating-mucoadhesive gliclazide metode desain faktorial. E-Jurnal Pustaka Kesehatan, 4(2), 249–254.
Syabania, M., Pambudi, D. B., Wirasti, W., & Rahmatullah, S. (2021). Karakteristik dan evaluasi granul ekstrak daun kersen (Muntingia calabura L.) dengan metode granulasi basah. Prosiding Seminar Nasional Kesehatan, 1, 1737–1746. https://doi.org/10.48144/prosiding.v1i.926
Tarizza Puspa Anggrelia, Ginting, A. S., Rosyidah, Y. K. I., Istifadah, M., Agustino, F., Rahmawati, D., Ambari, Y., Ariyanti, M. M., & Mubarak, M. F. (2024). Kajian penggunaan matriks pada formulasi tablet lepas lambat. Jurnal Anestesi, 2(3), 251–260. https://doi.org/10.59680/anestesi.v2i3.1249
United States Pharmacopenia (USP). (2014). The United States Pharmacopenia 37. United States Pharmacopenia Convention.
Wardhani, S. D., Nugroho, F., Yulianto, D., Azizah, S., & Wahyono, H. W. (2016). Formulasi tablet hisap kombinasi Curcuma xanthoriza Roxb., Curcuma longa L., dan Zingiber officinale ‘Sunti’ sebagai sediaan kemopreventif kanker. Acta Pharmaciae Indonesia.
Wathore, S. (2023). Formulation and evaluation of lamivudine extended release floating tablets by using HPMC polymers and xanthan gum. Journal of Pharmaceutical Research Internasional, 8(3), 262–273. https://doi.org/10.35629/7781-0803262273
Published
2025-11-25
How to Cite
Yunita, F., Nawangsari, D., & Febrina, D. (2025, November 25). Evaluasi Sifat Fisik Tablet Floating Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Dengan Kombinasi Xanthan Gum Dan HPMC Sebagai Polimer. Seminar Nasional Penelitian Dan Pengabdian Kepada Masyarakat 2025, 4(1), 38-46. https://doi.org/https://doi.org/10.35960/snppkm.v4i1.1401
Section
Penelitian
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